Oxidative stress plays a crucial role in the salivary gland dysfunction in insulin resistance (IR). It is not surprising that new\nsubstances are constantly being sought that will protect against the harmful effects of IR in the oral cavity environment. The\npurpose of this study was to evaluate the effect of N-acetylcysteine (NAC) on oxidative stress and secretory function of salivary\nglands in a rat model of insulin resistance. Rats were divided into 4 groups: Cââ?¬â?normal diet, C +NACââ?¬â?normal diet + NAC,\nHFDââ?¬â?high-fat diet, and HFD+ NAC. We have demonstrated that NAC elevated enzymatic (superoxide dismutase, catalase,\nand peroxidase) and nonenzymatic antioxidants (reduced glutathione (GSH) and total antioxidant capacity (TAS)) in the\nparotid glands of HFD +NAC rats, while in the submandibular glands increased only GSH and TAS levels. NAC protects\nagainst oxidative damage only in the parotid glands and increased stimulated salivary secretion; however, it does not increase\nthe protein secretion in the both salivary glands. Summarizing, NAC supplementation prevents the decrease of stimulated saliva\nsecretion, seen in the HFD rats affected. NAC improves the antioxidative capacity of the both glands and protects against\noxidative damage to the parotid glands of IR rats.
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